Prodromal dementia with Lewy bodies

  title={Prodromal dementia with Lewy bodies},
  author={Paul C. Donaghy and John Tiernan O'Brien and Alan J. Thomas},
  journal={Psychological Medicine},
  pages={259 - 268}
Background The clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This paper reviews the evidence for the clinical presentation of prodromal dementia with Lewy bodies (DLB). Method A Medline search was carried out… 
The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review
The findings indicate thatDLB-MCI patients have a pattern of executive, visuospatial, and attentional deficits, and the shortage of studies clearly underlines the paucity of published research into DLB- MCI and emphasizes the need for well-controlled studies.
The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body Dementias
The findings of this systematic review indicate similar neuropsychological profiles in the MCI stages of DLB and PDD may at least partially explain poor performance in other domains.
Dementia with Lewy bodies — from scientific knowledge to clinical insights
Clinical insights for the basic scientist and a basic science foundation for the clinician are provided and increased understanding of the genetics and pathology of the condition is growing, feeding through to new therapeutic strategies and clinical trials.
Cognitive and Neuropsychiatric Features in Parkinson's and Lewy Body Dementias.
  • J. Fields
  • Psychology, Medicine
    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
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This review will focus on the cognitive and neuropsychiatric features of Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), with emphasis on neuropsychological findings.
Behavioral symptomatology and psychopharmacology of Lewy body dementia.
Exploring the Phenotype in Mild Cognitive Impairment to Aid the Prediction of Those at Risk of Transitioning to Parkinson Disease and Dementia With Lewy Bodies
It is suggested that targeting nonamnestic MCI patients who report RBD with additional biomarker testing including smell, color vision, and neuroimaging may aid in early diagnosis and prediction of these α-synucleinopathies.
Neuropsychiatric profiles in mild cognitive impairment with Lewy bodies
The NPI is a useful tool to detect NPS in those with MCI-LB, which had a higher prevalence of core features (visual hallucinations and RBD) and a higher LBNSSC than theMCI-AD group.
Early autonomic and cognitive dysfunction in PD, DLB and MSA: blurring the boundaries between α-synucleinopathies
Early coexistence of autonomic and cognitive dysfunction in the setting of overt or latent parkinsonism as pitfalls in the differential diagnosis of α-synucleinopathies is focused on.
Diagnosis of Lewy Body Dementia at the Prodromal Stage
This review addresses approaches to the early and more accurate detection of Lewy body dementia and prognostication of the course of disease, as well as problems of the optimum treatment of disease.
Lewy Body Spectrum Disorders: from Dementia with Lewy Bodies to Parkinson’s Disease Dementia
Recent advances in the study of Lewy body disorders are discussed and how to apply them to clinical practice are discussed.


Diagnosis and management of dementia with Lewy bodies
The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count.
Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease
Dementia with Lewy bodies: early diagnostic challenges
A conceptual framework is proposed to identify these symptomatic but non‐demented individuals that led to suspect the underlying pathophysiology of Lewy body disease and further prospective study is warranted to determine the clinical significance of LB‐related symptoms in non‐Demented patients.
Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies
Inclusion of RBD as a core clinical feature improves the diagnostic accuracy of autopsy-confirmed DLB.
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
It could be more appropriate, for a consensus statement, to conclude that finding EEG abnormalities does not exclude the diagnosis of LBD, instead of asserting that EEG abnormalities support LBD diagnosis.
Mild cognitive impairment as a diagnostic entity
  • R. Petersen
  • Psychology, Medicine
    Journal of internal medicine
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It is suggested that the diagnosis of mild cognitive impairment can be made in a fashion similar to the clinical diagnoses of dementia and AD, and an algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI.
Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease.
Loss of ChAT activity is less severe and occurs later in the clinical course of AD, suggesting that cholinergic replacement therapy may be more effective in LBV than in AD, especially in mild-stage disease.
Validation of the Neuropathologic Criteria of the Third Consortium for Dementia With Lewy Bodies for Prospectively Diagnosed Cases
The Third Consortium on DLB neuropathologic criteria scheme performed reasonably well and are useful for estimating the likelihood of the premortem DLB syndrome based on postmortem findings and may be modified to consider cases with neurofibrillary tangle stage VI to be low-likelihood DLB.
[Neuropathology of mild cognitive impairment].
  • M. Takao
  • Psychology, Biology
    Rinsho shinkeigaku = Clinical neurology
  • 2012
To realize the complexity of neuropathologic alterations of MCI is important for early intervention of dementia indivisuals.
Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study.
Among Lewy body disease cases that pass through a mild cognitive impairment stage, any cognitive pattern or mild cognitive subtype is possible, with the attention/executive and visuospatial domains most frequently impaired.