Corpus ID: 44762826

Prodigiosin as anticancer drug Produced from bacteria of termite gut

@inproceedings{Gowralkar2013ProdigiosinAA,
  title={Prodigiosin as anticancer drug Produced from bacteria of termite gut},
  author={Maheswarappa Gowralkar},
  year={2013}
}
Prodigiosin, a natural red pigment produced by Serratia sp, Pseudomonas sp, Streptomyces sp and Vibrio sp . It is an alkaloid secondary metabolite with a unique tripyrrol structure. This pigment has been reported to have antibacterial, antifungal, antimalarial and antineoplastic activity. Prodigiosins are produced in more concentration by Serratia marcescens. In this study, Serratia marcescens was isolated from termite gut, identified and characterized by morphology, gram’s staining… Expand

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References

SHOWING 1-10 OF 18 REFERENCES
Purification and characterization of prodigiosin produced by integrated bioreactor from Serratia sp. KH-95.
TLDR
This downstream procedure that uses the integrated bioreactor can be applied to the direct production and purification of other prodigiosin analogues and hydrophobic alkaloid compounds from several microorganisms. Expand
Anticancer activity of red pigment from Serratia marcescens in human cervix carcinoma.
TLDR
Results suggested that the prodigiosin has strong anticancer and apoptosis activity against human cervical carcinoma cancer. Expand
Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines
TLDR
Results indicate that prodigiosin, an immunosuppressor, induces apoptosis in haematopoietic cancer cells with no marked toxicity in nonmalignant cells, raising the possibility of its therapeutic use as an antineoplastic drug. Expand
Prodigiosin-induced apoptosis in human colon cancer cells.
TLDR
It is confirmed that prodigiosin induces apoptosis in both cancer cell lines by the characteristic DNA laddering pattern and condensed nuclei or apoptotic bodies identified by fluorescence microscopy. Expand
Review of Prodigiosin, Pigmentation in Serratia marcescens
TLDR
In present study, the production condition, physicochemical and functional characteristics, structure, genetic and gene expression, apoptosis and toxigenic effects of prodigiosin will be discussed in-order to contribute to the world of Serratia marcescens with respect to its prodigioin production property. Expand
Prodigiosin Production by Serratia marcescens UCP 1549 Using Renewable-Resources as a Low Cost Substrate
TLDR
The objective of this work was to indentify a suitable medium to simultaneously enhance S. marcescens growth and pigment production using renewable resources obtained from industrial wastes and to design a new, economically feasible medium supporting enhanced S. Marcescensgrowth and prodigiosin production. Expand
Extracellular Vesicle Formation and Biosurfactant Production by Serratia marcescens
TLDR
Pigmented and non-pigmented strains of Serratia marcescens produced extracellular vesicles and had wetting activity when grown at 30°C but not at 37°C, and wetting agent and prodigiosin (in a pigmented strain) were the main lipids of isolated vesicle. Expand
Immunomodulating properties of prodigiosin 25-C, an antibiotic which preferentially suppresses induction of cytotoxic T cells.
TLDR
Prodigiosin 25-C moderately prolonged survival of major histocompatibility (MHC)-mismatched skin grafts and potential usefulness of the antibiotic for a supplementary immunosuppressant are demonstrated. Expand
Separation of the Prodigiosin‐Localizing Crude Vesicles Which Retain the Activity of Protease and Nuclease in Serratia marcescens
TLDR
The profiles of the activities of the protease and the nuclease in the fractions were different from each other, suggesting that the two extracellular enzymes were released from the pigmented bacteria by different mechanisms. Expand
Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia
TLDR
It is demonstrated that prodigiosin induces apoptosis of B-cell chronic lymphocytic leukemia (B-CLL) cells (n=32 patients) and the dose–response for the cytotoxic effect of prodigioin was analyzed in cells from 12 patients showing an IC50 of 116±25 nM. Expand
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