Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy

  title={Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy},
  author={Christine Lund Kragh and Amanda M. Gysbers and Edward M. Rockenstein and Karen Murphy and Poul Henning Jensen},
  journal={Neurobiology of Disease},
Multiple system atrophy is a progressive, neurodegenerative disease characterized by parkinsonism, ataxia, autonomic dysfunction, and accumulation of α-synuclein in oligodendrocytes. To understand how α-synuclein aggregates impact oligodendroglial homeostasis, we investigated an oligodendroglial cell model of α-synuclein dependent degeneration and identified responses linked to the NF-κB transcription factor stress system. Coexpression of human α-synuclein and the oligodendroglial protein p25… CONTINUE READING
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