Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury.

@article{Chen2009ProdeathOP,
  title={Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury.},
  author={Wanqiu Chen and Robert P Ostrowski and Andre Obenaus and John H Zhang},
  journal={Experimental neurology},
  year={2009},
  volume={216 1},
  pages={7-15}
}
Hypoxia, which occurs in the brain when oxygen availability drops below the normal level, is a major cause of perinatal hypoxic-ischemic injury (HII). The transcriptional factor hypoxia inducible factor-1 (HIF-1) is a key regulator in the pathophysiological response to the stress of hypoxia. Genes regulated by HIF-1 are involved in energy metabolism, erythropoiesis, angiogenesis, vasodilatation, cell survival and apoptosis. Compared with the adult brain, the neonatal brain is different in… CONTINUE READING