Prod is a novel DNA-binding protein that binds to the 1.686 g/cm(3) 10 bp satellite repeat of Drosophila melanogaster.

@article{Trk2000ProdIA,
  title={Prod is a novel DNA-binding protein that binds to the 1.686 g/cm(3) 10 bp satellite repeat of Drosophila melanogaster.},
  author={Tibor T{\"o}r{\"o}k and M{\'a}ty{\'a}s Gorj{\'a}n{\'a}cz and Peter J. Bryant and Ildik{\'o} Kiss},
  journal={Nucleic acids research},
  year={2000},
  volume={28 18},
  pages={3551-7}
}
The proliferation disrupter (prod) gene of Drosophila melanogaster encodes a novel protein associated with centromeric chromosomal regions that is required for chromatin condensation and cell viability. We have examined the binding of the Prod protein to DNA in vitro. Co-immunoprecipitation experiments demonstrate that Prod is a DNA-binding protein that specifically recognizes the 10 bp AGAATAACAT satellite repeat of D.melanogaster. Footprinting experiments show that the protein interacts with… CONTINUE READING