Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol.

@article{Verstraeten2013ProcyanidinsCI,
  title={Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol.},
  author={Sandra V Verstraeten and Grayson K Jaggers and Cesar G Fraga and Patricia I Oteiza},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1828 11},
  pages={2646-53}
}
Large procyanidins (more than three subunits) are not absorbed at the gastrointestinal tract but could exert local effects through their interactions with membranes. We previously showed that hexameric procyanidins (Hex), although not entering cells, interact with membranes modulating cell signaling and fate. This paper investigated if Hex, as an example of large procyanidins, can selectively interact with lipid rafts which could in part explain its biological actions. This mechanism was… CONTINUE READING
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