Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition.

@article{Ottaviani2006ProcyanidinSD,
  title={Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition.},
  author={Javier I. Ottaviani and Lucas Actis-Goretta and Juan J Villordo and Cesar G Fraga},
  journal={Biochimie},
  year={2006},
  volume={88 3-4},
  pages={359-65}
}
Recent reports have shown a decrease in blood pressure associated with the consumption of flavanol-containing foods. However, the mechanism behind this effect is not yet known. Previously we demonstrated that the flavanol epicatechin and its related oligomers, the procyanidins, inhibit angiotensin I converting enzyme (ACE) activity in vitro. In this study, we further characterized epicatechin monomer, dimer, tetramer and hexamer ACE inhibitory effect, by performing fluorescence quenching and… CONTINUE READING

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