Proctor Lecture. Experimental allergic uveitis. Investigations of retinal autoimmunity and the immunopathologic responses evoked.

  • W B Wacker
  • Published 1991 in Investigative ophthalmology & visual science

Abstract

Waldon D. Uveitis is an inflammatory condition of the eye that is generally of unknown etiology. Although it may occur in association with systemic disorders, it most often occurs alone as a specific organ disease. It usually runs a chronic relapsing course that is difficult to manage clinically and may result in blindness. Infective agents as a cause have been established in only a few cases. However, diverse immunologic studies over the past century suggested that allergy or autoimmunity may be a factor in many instances. Historically, the main thrust for a role of autoimmunity in the pathogenesis of uveitis was provided by Elschnig in 1910, who proposed autoimmunity to uveal antigens as a mechanism of sympathetic ophthalmia. This appealing concept focused attention on the uvea as the source of antigens that might produce the disease experimentally. Few of the many attempts over the ensuing decades to produce an animal model of autoimmune uveitis were successful. With the aid of Freund's adjuvant, Collins in 1949 reported production of autoimmune uveitis in guinea pigs immu-

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Cite this paper

@article{Wacker1991ProctorLE, title={Proctor Lecture. Experimental allergic uveitis. Investigations of retinal autoimmunity and the immunopathologic responses evoked.}, author={W B Wacker}, journal={Investigative ophthalmology & visual science}, year={1991}, volume={32 13}, pages={3119-28} }