Procorticotrophin releasing hormone is endoproteolytically processed by the prohormone convertase PC2 but not by PC1 within stably transfected CHO-K1 cells.

Abstract

Hormones and neuropeptides are generally synthesized as large precursor molecules: i.e. prohormones and proneuropeptides which undergo endoproteolysis to produce biologically active peptides. Corticotrophin releasing hormone (CRH) is a 41 aminoacid peptide which plays a major role in the regulation of the endocrine response to stress. CRH( 1-41) is… (More)

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