Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the rat.

@article{Foote1984ProconvulsantEO,
  title={Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the rat.},
  author={Franklin M. Foote and Karen N Gale},
  journal={European journal of pharmacology},
  year={1984},
  volume={105 1-2},
  pages={179-84}
}
The chemoconvulsant pentylenetetrazol (PTZ) was administered by a variety of routes to rats pretreated with morphine (10-50 mg/kg s.c.). In a naloxone-reversible, dose-dependent manner, morphine decreased the threshold for seizures induced by the slow intravenous infusion of PTZ. In addition, morphine increased the severity of seizures induced by the intravenous, intraperitoneal, and subcutaneous routes of administration of PTZ. Morphine also caused an increased incidence of multiple seizures… CONTINUE READING