Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny.

@article{Bernkov2000ProconvulsantEO,
  title={Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny.},
  author={Kl{\'a}ra Bern{\'a}{\vs}kov{\'a} and Pavel Mare{\vs}},
  journal={Epilepsy research},
  year={2000},
  volume={39 3},
  pages={183-90}
}
Effect of aminophylline on epileptic afterdischarges (ADs) induced repeatedly by rhythmic electrical stimulation of sensorimotor cortical area was studied in rat pups 12, 18 and 25 days old. The proconvulsant effect of aminophylline (50 and/or 100 mg/kg i.p.) was more expressed in 12- and 18-day-old rats than in the oldest group. In 12-day-old rat pups there was an enormous increase of transition of the spike-and-wave type of ADs into the second, limbic type, a situation observed only… CONTINUE READING

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