Procollagen trafficking, processing and fibrillogenesis.

  title={Procollagen trafficking, processing and fibrillogenesis.},
  author={Elizabeth G. Canty and Karl E Kadler},
  journal={Journal of cell science},
  volume={118 Pt 7},
Collagen fibrils in the extracellular matrix allow connective tissues such as tendon, skin and bone to withstand tensile forces. The fibrils are indeterminate in length, insoluble and form elaborate three-dimensional arrays that extend over numerous cell lengths. Studies of the molecular basis of collagen fibrillogenesis have provided insight into the trafficking of procollagen (the precursor of collagen) through the cellular secretory pathway, the conversion of procollagen to collagen by the… CONTINUE READING
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