Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis.

@article{Milani1990ProcollagenEB,
  title={Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis.},
  author={Stefano Milani and Hermann Herbst and Detlef B Schuppan and Ki Young Kim and E. O. Riecken and Harald Von Stein},
  journal={Gastroenterology},
  year={1990},
  volume={98 1},
  pages={175-84}
}
To localize the cellular sources of the collagens excessively deposited in the liver in the course of secondary biliary fibrosis, we have analyzed by in situ hybridization the distribution of alpha 2(I), alpha 1(III), and alpha 1(IV) procollagen and albumin RNA transcripts in rat livers up to 6 wk following common bile duct ligation and scission. In normal liver, moderate amounts of alpha 2(I) and alpha 1(III) procollagen RNA were found in nonparenchymal cells, while alpha 1(IV) procollagen… CONTINUE READING
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