Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence.

Abstract

BACKGROUND The signal(s) for removal of senescent platelets from the circulation are not fully understood; phosphatidylserine (PS) expression on platelets and another marker of apoptosis, loss of mitochondrial inner membrane potential (DeltaPsim), have been implicated in platelet clearance. OBJECTIVE To investigate whether shortened platelet survival and… (More)

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