Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis.

@article{Zhuang2010ProcessivityFO,
  title={Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis.},
  author={Zhihao Zhuang and Yongxing Ai},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1804 5},
  pages={1081-93}
}
Clamp protein or clamp, initially identified as the processivity factor of the replicative DNA polymerase, is indispensable for the timely and faithful replication of DNA genome. Clamp encircles duplex DNA and physically interacts with DNA polymerase. Clamps from different organisms share remarkable similarities in both structure and function. Loading of clamp onto DNA requires the activity of clamp loader. Although all clamp loaders act by converting the chemical energy derived from ATP… CONTINUE READING

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