Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions.

@article{Zhao2011ProcessiveAD,
  title={Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions.},
  author={Yong Zhao and Eladio B. Abreu and Jinyong Kim and Guido Stadler and Uğur Eskiocak and Michael P Terns and Rebecca M. Terns and Jerry W Shay and Woodring E Wright},
  journal={Molecular cell},
  year={2011},
  volume={42 3},
  pages={
          297-307
        }
}
Specific information about how telomerase acts in vivo is necessary for understanding telomere dynamics in human tumor cells. Our results imply that, under homeostatic telomere length-maintenance conditions, only one molecule of telomerase acts at each telomere during every cell division and processively adds ∼60 nt to each end. In contrast, multiple molecules of telomerase act at each telomere when telomeres are elongating (nonequilibrium conditions). Telomerase extension is less processive… CONTINUE READING
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