Processive RNA polymerization and promoter recognition in an RNA World

@article{Cojocaru2021ProcessiveRP,
  title={Processive RNA polymerization and promoter recognition in an RNA World},
  author={Razvan Cojocaru and Peter J. Unrau},
  journal={Science},
  year={2021},
  volume={371},
  pages={1225 - 1232}
}
A processive RNA replicator The RNA World Hypothesis suggests that, before modern life, there were RNA molecules that were capable of carrying genetic information and driving chemical reactions, a task gradually replaced by DNA and enzymes in modern biology. Central to this theory is an RNA replicase capable of mediating general replication of RNA. Using laboratory evolution, Cojocaru et al. isolated a promoter-based RNA polymerase ribozyme that, analogous to modern-day protein polymerases… 

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  • 2021
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