Processing, secretion, and anti-HIV-1 activity of IL-16 with or without a signal peptide in CD4+ T cells.

Abstract

CD4+ T cells transfected with the C-terminal 130 aa of human IL-16 are rendered resistant to HIV infection. Whether the constitutively expressed IL-16 acts intracellularly, extracellularly, or both is not clear. To address this question and to further study the processing of IL-16, new constructs containing either the C-terminal 130 aa or the C-terminal 100… (More)

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Cite this paper

@article{Zhou1999ProcessingSA, title={Processing, secretion, and anti-HIV-1 activity of IL-16 with or without a signal peptide in CD4+ T cells.}, author={Pan-yu Zhou and Krishnakumar Devadas and Deepanker Tewari and A Jegorow and Abner Louis Notkins}, journal={Journal of immunology}, year={1999}, volume={163 2}, pages={906-12} }