Processing of tumour necrosis factor-alpha precursor by metalloproteinases.

  title={Processing of tumour necrosis factor-alpha precursor by metalloproteinases.},
  author={Andrew J. H. Gearing and Paul Beckett and Michel Christodoulou and Melissa Churchill and John M. Clements and Ann H Davidson and Alan H. Drummond and Walter Galloway and Ralph Gilbert and John L. Gordon},
  volume={370 6490},
Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, multiple sclerosis and the cachexia associated with cancer or human immunodeficiency virus infection. TNF-alpha is initially expressed as a 233-amino-acid membrane-anchored precursor which is proteolytically processed to yield the mature, 157-amino-acid cytokine. The processing enzyme(s) which cleave TNF-alpha… CONTINUE READING
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