Processing of transforming growth factor beta 1 precursor by human furin convertase.

@article{Dubois1995ProcessingOT,
  title={Processing of transforming growth factor beta 1 precursor by human furin convertase.},
  author={Claire M Dubois and M H Laprise and François Blanchette and Larry E. Gentry and Richard Leduc},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 18},
  pages={10618-24}
}
Proteolytic processing of the transforming growth factor beta precursor (pro-TGF beta) is an essential step in the formation of the biologically active TGF beta homodimeric protein (TGF beta). The 361-amino-acid precursor pro-TGF beta 1 has within its primary structure the R-H-R-R processing signal found in many constitutively secreted precursor proteins and potentially recognized by members of the mammalian convertase family of endoproteases. To determine whether cleavage of pro-TGF beta 1 can… CONTINUE READING

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