Processing of the circumsporozoite protein in infected hepatocytes is not dependent on aspartic proteases.

Abstract

CD8(+) T cells play a major role in the protective immune response against the liver stage of malaria. It was previously shown that the circumsporozoite protein (CSP) is processed and presented to specific T cells by both traversed and infected hepatocytes, but their respective antigen processing requirements were not completely defined. In the present… (More)
DOI: 10.1111/j.1365-3024.2008.01032.x

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