Processing of the carboxyl 15-amino acid extension in the alpha-chain of fibrinogen.

@article{Farrell1993ProcessingOT,
  title={Processing of the carboxyl 15-amino acid extension in the alpha-chain of fibrinogen.},
  author={David H Farrell and S M Huang and Earl W. Davie},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 14},
  pages={10351-5}
}
The cDNA for the alpha-chain of human fibrinogen codes for 15 amino acids at the carboxyl terminus that are not found in the native protein circulating in plasma. In the present studies, experiments were designed to test whether the carboxyl extension was required for fibrinogen assembly or was simply the result of limited proteolysis and maturation of the protein during or following secretion. Baby hamster kidney cells were transfected with cDNAs coding for the alpha-, beta-, and gamma-chains… CONTINUE READING