Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs.

@article{Falaleeva2013ProcessingOS,
  title={Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs.},
  author={Marina Falaleeva and Stefan Stamm},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2013},
  volume={35 1},
  pages={46-54}
}
Recent experimental evidence suggests that most of the genome is transcribed into non-coding RNAs. The initial transcripts undergo further processing generating shorter, metabolically stable RNAs with diverse functions. Small nucleolar RNAs (snoRNAs) are non-coding RNAs that modify rRNAs, tRNAs, and snRNAs that were considered stable. We review evidence that snoRNAs undergo further processing. High-throughput sequencing and RNase protection experiments showed widespread expression of snoRNA… CONTINUE READING

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