Processing of ring saturation and fragmentation products of DNA thymine in Escherichia coli.

@article{Wallace1989ProcessingOR,
  title={Processing of ring saturation and fragmentation products of DNA thymine in Escherichia coli.},
  author={Susan S. Wallace},
  journal={Annali dell'Istituto superiore di sanita},
  year={1989},
  volume={25 1},
  pages={191-201}
}
The biological processing of thymine ring saturation and fragmentation products is summarized in Table 1. The ring saturation product, thymine glycol, is a block to in vitro DNA synthesis, whereas the ring saturation product, dihydrothymine, is not. Both these lesions are recognized in vitro by endonucleases III and VIII. Since thymine glycol is a replicative block, it is a lethal lesion in vivo. The excision repair process for removal of thymine glycols from DNA is initiated in vivo by… CONTINUE READING