Processing of proteinase precursors and their effect on hepatitis A virus particle formation.

@article{Probst1998ProcessingOP,
  title={Processing of proteinase precursors and their effect on hepatitis A virus particle formation.},
  author={Christian Probst and M. Jecht and Verena Gauss-M{\"u}ller},
  journal={Journal of virology},
  year={1998},
  volume={72 10},
  pages={8013-20}
}
Proteolytic processing of the picornaviral polyprotein mediated by the differential action of virus-encoded proteinase(s) is pivotal to both RNA genome replication and capsid formation. Possibly to enlarge the array of viral proteins, picornaviral polyprotein processing results in intermediate and mature products which apparently have distinct functions within the viral life cycle. For hepatitis A virus (HAV), we report here on the autoproteolysis of precursor polypeptides comprising the only… CONTINUE READING

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