Processing of precursor interleukin 1 beta and inflammatory disease.

Abstract

The processing of precursor interleukin 1 beta (IL1 beta) by elastase, cathepsin G, and collagenase, the major proteases released at sites of inflammation, was investigated using recombinant pro-IL1 beta. Each of these proteases cleaved the 31-kDa inactive precursor to a form similar in size and specific activity (greater than 10(8) units/mg) to the 17-kDa… (More)

Topics

Cite this paper

@article{Hazuda1990ProcessingOP, title={Processing of precursor interleukin 1 beta and inflammatory disease.}, author={Daria J. Hazuda and Jennifer Strickler and Friedrich Kueppers and Petr Simon and P. R. Young}, journal={The Journal of biological chemistry}, year={1990}, volume={265 11}, pages={6318-22} }