Processing of nerve growth factor: the role of basic amino acid clusters in the pro-region.

@article{Mouri2007ProcessingON,
  title={Processing of nerve growth factor: the role of basic amino acid clusters in the pro-region.},
  author={Akihiro Mouri and Hiroshi Nomoto and Shoei Furukawa},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={353 4},
  pages={1056-62}
}
Neurotrophins are synthesized first as precursors called pro-neurotrophins, and their propeptides are then proteolytically removed to form mature neurotrophins. However, a significant proportion of total neurotrophins has been shown to be secreted as pro-neurotrophins. Furthermore, pro- and mature neurotrophins have been shown to elicit opposite effects on cell survival. Thus, the processing step of neurotrophins is very important. In order to understand the mechanism of neurotrophin processing… CONTINUE READING
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