Processing of hydrophobic pulmonary surfactant protein B in rat type II cells.

  title={Processing of hydrophobic pulmonary surfactant protein B in rat type II cells.},
  author={Timothy E. Weaver and Jeffrey A. Whitsett},
  journal={The American journal of physiology},
  volume={257 2 Pt 1},
The amino acid sequence of surfactant protein B (SP-B), derived from human genomic and cDNA sequences, indicates that the active polypeptide is contained within the sequence of a preproprotein of 381 residues. Synthesis of mature SP-B, which requires proteolytic processing at both the NH2- and COOH-termini of the proprotein, was studied in primary cultures of rat alveolar type II epithelial cells. Type II cells were pulse labeled with [35S]methionine-cysteine for 15-30 min and chased for 0-18 h… CONTINUE READING


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