Processing of directly and indirectly ultraviolet-induced DNA damage in human cells.

@article{Rnger1995ProcessingOD,
  title={Processing of directly and indirectly ultraviolet-induced DNA damage in human cells.},
  author={Thomas M. R{\"u}nger and Bernd Epe and Kathrin M{\"o}ller},
  journal={Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer},
  year={1995},
  volume={139},
  pages={
          31-42
        }
}
Mutations caused by ultraviolet (UV)-induced DNA damage represent the initial genetic changes in the tumorigenesis of UV-induced skin cancer. Different wavelengths of UV radiation cause different kinds of DNA damage and mutations. UVB (290-320 nm) generates pyrimidine dimers by direct excitation of the DNA molecule. UVA (320-400 nm) can damage the DNA only indirectly through a photosensitized reaction. This indirect action is mediated mainly by singlet oxygen, which generates purine base… CONTINUE READING
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