Processing of chromogranins in chromaffin cell culture: effects of reserpine and alpha-methyl-p-tyrosine.

@article{Wolkersdorfer1996ProcessingOC,
  title={Processing of chromogranins in chromaffin cell culture: effects of reserpine and alpha-methyl-p-tyrosine.},
  author={M Wolkersdorfer and Andrea Laslop and Claude Lazure and Reiner Fischer-Colbrie and Heinz Winkler},
  journal={The Biochemical journal},
  year={1996},
  volume={316 ( Pt 3)},
  pages={953-8}
}
Bovine chromaffin cell cultures were treated with either reserpine or alpha-methyl-p-tyrosine for up to 10 days. Afterwards the cells were harvested and the degree of proteolytic processing of secretogranin II, chromogranin A and chromogranin B was determined by immunoblotting and HPLC followed by RIA. There was a significant increase in the proteolysis of… CONTINUE READING