Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.

@article{Haass1991ProcessingOB,
  title={Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.},
  author={Christian Haass and Albert Y. C. Hung and Dennis J Selkoe},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1991},
  volume={11 12},
  pages={3783-93}
}
Microglial cells and astrocytes are closely associated with nearly all compact deposits of the amyloid beta-protein found in the senile plaques characteristic of Alzheimer's disease and trisomy 21. The biosynthesis and metabolic fate of the beta-amyloid precursor protein (beta APP) in astrocytes has not been characterized, and its identification in microglia has not been described. Here, we report the expression of beta APP by astrocytes and microglia in primary cultures of cerebral cortex from… CONTINUE READING

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