Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme.

@article{Dooren2002ProcessingOA,
  title={Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme.},
  author={Giel G van Dooren and Vanessa Su and Marthe C. D'Ombrain and Geoffrey Ian McFadden},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 26},
  pages={23612-9}
}
The plastid (apicoplast) of the malaria-causing parasite Plasmodium falciparum was derived via a secondary endosymbiotic process. As in other secondary endosymbionts, numerous genes for apicoplast proteins are located in the nucleus, and the encoded proteins are targeted to the organelle courtesy of a bipartite N-terminal extension. The first part of this leader sequence is a signal peptide that targets proteins to the secretory pathway. The second, so-called transit peptide region is required… CONTINUE READING