Processing of amyloid precursor protein and amyloid peptide neurotoxicity.

  title={Processing of amyloid precursor protein and amyloid peptide neurotoxicity.},
  author={Pierrot Nathalie and Octave Jean-No{\"e}l},
  journal={Current Alzheimer research},
  volume={5 2},
Alzheimer's disease is characterized by the presence of two types of lesions in brain: neurofibrillary tangles and senile plaques. Intraneuronal neurofibrillary tangles are made of paired helical filaments containing hyperphosphorylated microtubule associated protein tau. Extracellular senile plaques contain a core of beta-amyloid peptide (Abeta), which is produced by cleavage of the Amyloid Precursor Protein (APP). Among the two catabolic pathways of APP, the amyloidogenic pathway producing… CONTINUE READING


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