Processing of Retinal Signals in Normal and HCN Deficient Mice

  title={Processing of Retinal Signals in Normal and HCN Deficient Mice},
  author={Luca Della Santina and Ilaria Piano and Lorenzo Cangiano and Antonella Caputo and Andreas Ludwig and Luigi Cervetto and Claudia Gargini},
  booktitle={PloS one},
This study investigates the role of two different HCN channel isoforms in the light response of the outer retina. Taking advantage of HCN-deficient mice models and of in vitro (patch-clamp) and in vivo (ERG) recordings of retinal activity we show that HCN1 and HCN2 channels are expressed at distinct retinal sites and serve different functions. Specifically, HCN1 operate mainly at the level of the photoreceptor inner segment from where, together with other voltage sensitive channels, they… CONTINUE READING


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Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
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