Processing of Precursor Interleukin 18 and Inflammatory Disease *

@inproceedings{Hazuda2001ProcessingOP,
  title={Processing of Precursor Interleukin 18 and Inflammatory Disease *},
  author={Daria Hazuda and James Stricklerll and Friedrich Kueppersll and Philip L. Simon and Peter Youngs},
  year={2001}
}
The processing of precursor interleukin 18 (ILlB) by elastase, cathepsin G, and collagenase, the major proteases released at sites of inflammation, was investigated using recombinant pro-IL1/3. Each of these proteases cleaved the 31-kDa inactive precursor to a form similar in size and specific activity (>lO’ units/mg) to the 17-kDa mature protein isolated… CONTINUE READING