Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct

@inproceedings{Tarassishin2004ProcessingON,
  title={Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct},
  author={Leonid Tarassishin and Ye Ingrid Yin and Bhramdeo Bassit and Yue-Ming Li},
  year={2004}
}
γ-Secretase activity is associated with a presenilin (PS)-containing macromolecular complex. Whether PS contains the active site of γ-secretase has been controversial. One challenge is to find PS that is engaged in the active γ-secretase complex at the cell surface, where some substrates appear to be processed. In this study, we developed an intact cell photolabeling technique that allows the direct visualization of active γ-secretase at the cell surface. We demonstrated that active γ-secretase… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

The structure and functions of the presenilins

  • Cellular and Molecular Life Sciences CMLS
  • 2005
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2006
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Is Alzheimer's disease a disorder of mitochondria-associated membranes?

  • Journal of Alzheimer's disease : JAD
  • 2010
VIEW 2 EXCERPTS
CITES BACKGROUND