Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells

@inproceedings{Povirk2012ProcessingOD,
  title={Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells},
  author={Lawrence F. Povirk},
  booktitle={ISRN molecular biology},
  year={2012}
}
Most DNA double-strand breaks (DSBs)formed in a natural environment have chemical modifications at or near the ends that preclude direct religation and require removal or other processing so that rejoining can proceed. Free radical-mediated DSBs typically bear unligatable 3'-phosphate or 3'-phosphoglycolate termini and often have oxidized bases and/or abasic sites near the break. Topoisomerase-mediated DSBs are blocked by covalently bound peptide fragments of the topoisomerase. Enzymes capable… CONTINUE READING