Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis.


CRISPR interference confers adaptive, sequence-based immunity against viruses and plasmids and is specified by CRISPR RNAs (crRNAs) that are transcribed and processed from spacer-repeat units. Pre-crRNA processing is essential for CRISPR interference in all systems studied thus far. Here, our studies of crRNA biogenesis and CRISPR interference in naturally… (More)
DOI: 10.1016/j.molcel.2013.05.001


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@article{Zhang2013ProcessingindependentCR, title={Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis.}, author={Yan Zhang and Nadja Heidrich and Biju Joseph Ampattu and Carl W. Gunderson and H Steven Seifert and Christoph Schoen and J{\"o}rg Vogel and Erik J Sontheimer}, journal={Molecular cell}, year={2013}, volume={50 4}, pages={488-503} }