Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA.

Abstract

RNA transfection of dendritic cells (DCs) was shown to be highly efficient in eliciting CD8+ and CD4+ T-cell responses. However, antigen presentation pathways involved in generation of human leukocyte antigen (HLA) class I and class II peptides have remained elusive. To analyze this we incubated mucin 1 (MUC1) RNA-transfected DCs with compounds known to… (More)

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@article{Drfel2005ProcessingAP, title={Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA.}, author={Daniela D{\"{o}rfel and Silke Appel and Frank Gruenebach and Markus Michael Weck and Martin M{\"{u}ller and Annkristin Heine and Peter Brossart}, journal={Blood}, year={2005}, volume={105 8}, pages={3199-205} }