Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.

@article{Zhang1992ProcessingAL,
  title={Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.},
  author={L Zhang and P. Madhan Mohan and Rugmani Padmanabhan},
  journal={Journal of virology},
  year={1992},
  volume={66 12},
  pages={7549-54}
}
Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5. 

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