Processing and activation of pro-interleukin-16 by caspase-3.

  title={Processing and activation of pro-interleukin-16 by caspase-3.},
  author={Yufeng Zhang and David M. Center and Der Min Wu and William W. Cruikshank and J Yuan and David W. Andrews and Hardy Kornfeld},
  journal={The Journal of biological chemistry},
  volume={273 2},
Interleukin-16, a proinflammatory cytokine produced in CD8(+) lymphocytes, is synthesized as a precursor protein (pro-IL-16). It is postulated that the C-terminal region of pro-IL-16 is cleaved, releasing bioactive IL-16. To characterize IL-16 cleavage, we transfected COS cells with a cDNA encoding a approximately 50-kDa form of pro-IL-16. Transfected COS cells released a approximately 20-kDa IL-16 cleavage product shown to consist of the 121 C-terminal residues of pro-IL-16 by immunoblotting… CONTINUE READING