Processing, signaling, and physiological function of chemerin.

  title={Processing, signaling, and physiological function of chemerin.},
  author={Andreas Mattern and Tristan Zellmann and Annette G Beck-Sickinger},
  journal={IUBMB life},
  volume={66 1},
Chemerin is an immunomodulating factor secreted predominantly by adipose tissue and skin. Processed by a variety of proteases linked to inflammation, it activates the G-protein coupled receptor chemokine-like receptor 1 (CMKLR1) and induces chemotaxis in natural killer cells, macrophages, and immature dendritic cells. Recent developments revealed the role of the nonsignaling chemerin receptor C-C chemokine receptor-like 2 (CCRL2) in inflammation. Besides further research establishing its link… CONTINUE READING
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