Processes of blue light-induced damage to retinal pigment epithelial cells lacking phagosomes.

@article{Pang1999ProcessesOB,
  title={Processes of blue light-induced damage to retinal pigment epithelial cells lacking phagosomes.},
  author={Ji-Jing Pang and Yuko Seko and Takashi Tokoro},
  journal={Japanese journal of ophthalmology},
  year={1999},
  volume={43 2},
  pages={103-8}
}
PURPOSE To experimentally clarify the processes of the changes induced by blue light directly on the retinal pigment epithelium (RPE) before the formation of phagosomes or the accumulation of lipofuscin. METHODS We developed a new experimental method in which primary cultured cells of very young pigmented rats were exposed to several intensities and durations of blue light (wavelength = 440+/-10 nm). RESULTS At 1.0 mW/cm2, the damage was limited to mitochondria. At 2.0 mW/cm2, the cytoplasm… CONTINUE READING