Processed and raw tomato consumption and risk of prostate cancer: a systematic review and dose–response meta-analysis

  title={Processed and raw tomato consumption and risk of prostate cancer: a systematic review and dose–response meta-analysis},
  author={Joe L Rowles and Katherine M Ranard and Catherine C Applegate and Sookyoung Jeon and Ruopeng An and John W Erdman},
  journal={Prostate Cancer and Prostatic Diseases},
BackgroundProstate cancer (PCa) is the second most frequently diagnosed cancer among men worldwide. Many epidemiological studies have found an inverse association between increased tomato consumption and PCa risk. This study aims to determine the associations between consumption of various types of tomato products and PCa risk and to investigate potential dose–response relationships.MethodsWe conducted a systematic review and dose–response meta-analysis of dietary tomato in relation to PCa… 

Dietary Tomato Consumption and the Risk of Prostate Cancer: A Meta-Analysis

The results of this meta-analysis indicated that tomato consumption was not related with the risk of prostate cancer.

A high consumption of tomato and lycopene is associated with a lower risk of cancer mortality: results from a multi-ethnic cohort

The results demonstrate the potential beneficial effects of a high dietary intake of tomato and lycopene on cancer death and further prospective studies are needed to explore the association.

Tomato consumption and intake of lycopene as predictors of the incidence of prostate cancer: the Adventist Health Study-2

Consumption of canned and cooked tomatoes may reduce the risk of prostate cancer because these products contain more available lycopene, and an observational study cannot exclude confounding by some unidentified, prostate cancer preventive factor.

Adolescent Plant Product Intake in Relation to Later Prostate Cancer Risk and Mortality in the NIH-AARP Diet and Health Study.

The findings do not provide strong evidence to suggest that adolescent plant product intake is associated with reduced PCa risk, and none of the plant products examined were associated consistently with all PCa outcomes.

Dietary Intake of Tomato and Lycopene and Risk of All-Cause and Cause-Specific Mortality: Results From a Prospective Study

In this large nationally representative sample of US adult population, tomato products, and lycopene intake were associated with lower risks of total and CVD mortality and moderate consumption of Lycopene was also related with a reduced cancer mortality.

Nutrition and prostate cancer: review of the evidence

The evidence on any potential association between diet and prostate cancer is weak, and the reductionist approach considering individual nutritional factors is not suitable, and conducting more observational studies or small randomised trials evaluating the impact ofindividual nutritional factors on prostate cancer will not bring further answers.

Dried Fruit Intake and Cancer: A Systematic Review of Observational Studies

Current available data provide some initial evidence that consumption of dried fruit may be associated with a lower cancer incidence or mortality in populations, and suggest that higher intake of raisins and other dried fruits may be important in the prevention of cancers of the digestive system.

Impact of lifestyle in prostate cancer patients. What should we do?

Prevention strategies and healthy lifestyles are associated with higher survival rates in PCa patients and screening for anxiety and the presence of symptoms related to mood disorders is essential in the patient's follow-up concerning their perception of the condition.

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Dietary micronutrients including lycopene, epigallocatechin gallate, sulforaphane, indole-3-carbinol, resveratrol, quercetin, curcumin & piperine play a key role in prostate cancer prevention and progression and therefore hold great promise for the future overall management of prostate cancer.



Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis

Higher dietary and circulating lycopene concentrations are inversely associated with PCa risk, and there was a trend for protection against PCa aggressiveness.

Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies.

It's suggested that tomato may play a modest role in the prevention of prostate cancer and the type and quantity of tomato products regarding their potential in preventing prostate cancer.

The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies.

  • M. EtminanB. TakkoucheF. Caamaño-Isorna
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2004
The results show that tomato products may play a role in the prevention of prostate cancer, however, this effect is modest and restricted to high amounts of tomato intake.

Tomato consumption and prostate cancer risk: a systematic review and meta-analysis

Overall, tomato intake may have a weak protective effect against prostate cancer, and further prospective studies are needed to explore the potential relationship between tomato consumption and prostate cancer risk.

A Prospective Study of Lycopene and Tomato Product Intake and Risk of Prostate Cancer

This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from prostate cancer, and evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration.

Lycopene and Risk of Prostate Cancer

It is demonstrated that higher lycopene consumption/circulating concentration is associated with a lower risk of PCa and if there are other factors in tomato products that might potentially decrease PCa risk and progression.

Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

Background Many epidemiologic studies have investigated the association between carotenoids intake and risk of Prostate cancer (PCa). However, results have been inconclusive. Methods We conducted a

Lycopene, tomato products and prostate cancer‐specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort

Future studies are needed to confirm the potential inverse association of consistently high lycopene intake with PCSM among men with high‐risk prostate cancers, as well as investigate the association between prediagnosis and postdiagnosis consumption of tomato products and prostate‐cancer specific mortality.

Fruits and Vegetables in Relation to Prostate Cancer in Japanese Men: The Japan Public Health Center-Based Prospective Study

  • R. TakachiM. Inoue for the Japan Public Health Center-Based Prospecti
  • Medicine
    Nutrition and cancer
  • 2010
It is suggested that consumption of fruits or vegetables may not be associated with the risk of either localized or advanced prostate cancer in Japanese men, however, the possibility of confounding by detection bias on therisk of localized cancer could not be totally ruled out.

Tea and lycopene protect against prostate cancer.

It is suggested that habitual drinking tea and intakes of vegetables and fruits rich in lycopene could lead to a reduced risk of prostate cancer in Chinese men.