Process signatures in glatiramer acetate synthesis: structural and functional relationships

Abstract

Glatiramer Acetate (GA) is an immunomodulatory medicine approved for the treatment of multiple sclerosis, whose mechanisms of action are yet to be fully elucidated. GA is comprised of a complex mixture of polypeptides with different amino acid sequences and structures. The lack of sensible information about physicochemical characteristics of GA has… (More)
DOI: 10.1038/s41598-017-12416-1

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