Process quality engineering for bioreactor-driven manufacturing of tissue-engineered constructs for bone regeneration.

@article{Ir2013ProcessQE,
  title={Process quality engineering for bioreactor-driven manufacturing of tissue-engineered constructs for bone regeneration.},
  author={Ioannis Papantoniou Ir and Yoke Chin Chai and Frank P. Luyten and Jan Schrooten Ir},
  journal={Tissue engineering. Part C, Methods},
  year={2013},
  volume={19 8},
  pages={
          596-609
        }
}
The incorporation of Quality-by-Design (QbD) principles in tissue-engineering bioprocess development toward clinical use will ensure that manufactured constructs possess prerequisite quality characteristics addressing emerging regulatory requirements and ensuring the functional in vivo behavior. In this work, the QbD principles were applied on a manufacturing process step for the in vitro production of osteogenic three-dimensional (3D) hybrid scaffolds that involves cell matrix deposition on a… CONTINUE READING

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