Process parameter shifting: Part II. Biphasic cultivation-A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells.

@article{Trummer2006ProcessPS,
  title={Process parameter shifting: Part II. Biphasic cultivation-A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells.},
  author={Evelyn Trummer and Katharina Fauland and Silke Seidinger and Kornelia Schriebl and Christine Lattenmayer and Renate Kunert and Karola Vorauer-Uhl and Robert Weik and Nicole Borth and Hermann Katinger and Dethardt Mueller},
  journal={Biotechnology and bioengineering},
  year={2006},
  volume={94 6},
  pages={
          1045-52
        }
}
Regulation of cell growth and protein expression potentially results in a sustainable enhancement of the volumetric productivity in a fermentation process. Following a biphasic cultivation strategy the process initially passes through a cell proliferation phase to generate a sufficiently high viable cell mass. In the subsequent production phase cells are maintained viable and productive without significant cell proliferation leading to increased viable cell days and product yields. In a… CONTINUE READING
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