Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling.

@article{Bitterlich2015ProcessPD,
  title={Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling.},
  author={A Bitterlich and Cheryl Laabs and Isabell Krautstrunk and M Dengler and Michael Juhnke and Arnaud Grandeury and Heike Bunjes and Arno Kwade},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2015},
  volume={92},
  pages={171-9}
}
The production of nanosuspensions has proved to be an effective method for overcoming bioavailability challenges of poorly water soluble drugs. Wet milling in stirred media mills and planetary ball mills has become an established top-down-method for producing such drug nanosuspensions. The quality of the resulting nanosuspension is determined by the stability against agglomeration on the one hand, and the process parameters of the mill on the other hand. In order to understand the occurring… CONTINUE READING