Process of biosynthetic protein folding determines the rapid formation of native structure.

@article{Fedorov1999ProcessOB,
  title={Process of biosynthetic protein folding determines the rapid formation of native structure.},
  author={Academician N. A. Fedorov and Thomas O. Baldwin},
  journal={Journal of molecular biology},
  year={1999},
  volume={294 2},
  pages={579-86}
}
Biosynthetic folding, beginning with the growing nascent chain and leading to the biologically active structure within its proper cellular context, is one function shared by all proteins. We show that the bacterial luciferase beta subunit reaches its final native form in the alphabeta heterodimer much more rapidly during biosynthetic folding than during refolding from urea. The rate of formation of active enzyme is determined by a short-lived folding intermediate, which is able to associate… CONTINUE READING

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