Process of Fragment-Based Lead Discovery-A Perspective from NMR.

  title={Process of Fragment-Based Lead Discovery-A Perspective from NMR.},
  author={Rongsheng Ma and Pengchao Wang and Jihui Wu and Ke Ruan},
  volume={21 7}
Fragment-based lead discovery (FBLD) has proven fruitful during the past two decades for a variety of targets, even challenging protein-protein interaction (PPI) systems. Nuclear magnetic resonance (NMR) spectroscopy plays a vital role, from initial fragment-based screening to lead generation, because of its power to probe the intrinsically weak interactions between targets and low-molecular-weight fragments. Here, we review the NMR FBLD process from initial library construction to lead… CONTINUE READING


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